Enhancing the Evidence Base for Cost-Effectiveness Analysis in Ireland: Building Improvements from the Intervention-Specific to System-Wide Levels

Project status

In progress



Last updated

Tue, 2019-07-30 16:39

Dr James O’Mahony is leading this Health Research Board Emerging
Investigator Award (EIA) which contains three principal components. The first addresses the
theoretical and empirical basis for the cost-effectiveness threshold
used to determine if an intervention represents good value for money.
The second examines common methodological problems in
cost-effectiveness analyses of cancer screening and proposes a simple
simulation modelling framework for use as a teaching and method
research tool to help avoid such problems. The final component uses
microsimulation modelling to simulate the cost-effectiveness of novel
triage techniques for women tested as positive for the human
papillomavirus (HPV) at primary screening and to investigate the
potential of HPV self-sampling for the prevention of cervical cancer
in women who do not typically participate in cervical screening. Dr
O’Mahony is accompanied on the EIA programme by doctoral candidate Ms
Yi-Shu Lin. James and Yi-Shu work conjunction with the CERVIVA
multi-disciplinary research consortium, which investigates the
diagnosis and prevention of HPV-associated cancers. Other research
partners on the programme include participants based at the Royal
College of Surgeons in Ireland and the Erasmus Medical Centre,

Study co-ordinators