Dr Prerna Tewari, CERVIVA HRB ICE Fellow, was recently awarded best oral presentation at the British Society for Colposcopy & Cervical Pathology (BSCCP) 2016 meeting. The winning presentation was on the role of triage markers (e.g. HPV mRNA, p16/Ki67) in the management of HPV positive women presenting at colposcopy with minor cytological abnormalities.
The management of cervical disease has been improved by the recent incorporation of HPV testing protocols into cervical screening programmes. However, the specificity of HPV DNA testing is limited due to the high prevalence of transient HPV infections. Dr Tewari evaluated alternative options (such as HPV 16/18 genotyping, HPV mRNA testing, p16/Ki67 expression) to triage HPV positive women presenting in colposcopy. The study found that the specificity of HPV testing can be improved by including additional biomarkers as tests of disease.